Manslaughter Marsdale first appeared in The Amazing Spider-Man #271 (September 1985), created by Tom DeFalco and Ron Frenz. He was an enforcer for Madame Fang, a crime boss who ran a boxing gym in New York. He had a condition called analgesia, which made him unable to feel pain due to an unspecified operation. He also wore a pair of knuckle-dusters as his weapons of choice.

One of his first encounters with Spider-Man was when he tried to intimidate Bobby Chance, a boxer who wanted to leave Madame Fang’s gym. He was also confronted by Crusher Hogan, a former wrestler who had a connection to Spider-Man’s origin. Spider-Man intervened and defeated Manslaughter and his thugs, saving Bobby and Crusher.

Manslaughter later resurfaced as a member of the Zodiac, a group of villains who used astrological signs as their codenames. He was loyal to the leader of the Zodiac, who claimed to have revived him from a coma. However, it was later revealed that the Zodiac leader was the one who put him in a coma in the first place to steal his powers. The Zodiac clashed with several heroes, including Spider-Man, Iron Man, Hawkeye, and Wolverine.

Manslaughter Marsdale has not appeared in any other media besides comic books. However, he has some similarities to another Marvel villain, Tombstone, who also has superhuman strength and durability and works as an enforcer for crime bosses. Tombstone has appeared in several animated shows and video games featuring Spider-Man.

Manslaughter Marsdale is not a well-known or popular character, but he has some interesting aspects that make him stand out among other villains. His inability to feel pain gives him an edge in combat but also makes him reckless and overconfident. His loyalty to the Zodiac leader shows he is easily manipulated and deceived. His rivalry with Spider-Man and other heroes shows he is not afraid to challenge anyone who stands in his way.